{"result":[{"lastName":"Feng","clinicalFocus":[],"appointments":[{"appointment":"Assistant Professor,Molecular & Cellular Physiology"}],"primaryAppointment":"Assistant Professor,Molecular & Cellular Physiology","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=35054&type=small&showNoImage","displayName":"Liang Feng","firstName":"Liang","href":"http://mcp.stanford.edu/profiles/Liang_Feng","researchInterest":"We are interested in the structure, dynamics and function of eukaryotic transport proteins mediating ions and major nutrients crossing the membrane, the kinetics and regulation of transport processes, the catalytic mechanism of membrane embedded enzymes and the development of small molecule modulators based on the structure and function of membrane proteins."},{"lastName":"Vasquez","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Molecular & Cellular Physiology"}],"primaryAppointment":"Postdoctoral Research fellow, Molecular & Cellular Physiology","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=12553&type=small&showNoImage","displayName":"Valeria Vasquez","firstName":"Valeria","href":"http://mcp.stanford.edu/profiles/Valeria_Vasquez","researchInterest":""},{"lastName":"Levitt","clinicalFocus":[],"appointments":[{"appointment":"Professor,Structural Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Professor (By courtesy),Computer Science"}],"primaryAppointment":"Professor,Structural Biology","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=4494&type=small&showNoImage","displayName":"Michael Levitt","firstName":"Michael","href":"http://mcp.stanford.edu/profiles/Michael_Levitt","researchInterest":"having pioneered, we (a) predict folding of a polypeptide and RNA chains into a unique native-structure, we (b) model protein structure using the well-established paradigms that similar protein sequences imply similar three-dimensional structures, and (c) we are focusing on mesoscale modeling of large macromolecular complexes such as RNA polymerase and the mammalian chaperonin."},{"lastName":"McKay","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Structural Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Structural Biology","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=4099&type=small&showNoImage","displayName":"David B. McKay","firstName":"David","href":"http://mcp.stanford.edu/profiles/David_McKay","researchInterest":"Three-dimensional structure determination and biophysical studies of macromolecules."},{"lastName":"Jardetzky","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Chemical and Systems Biology"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Chemical and Systems Biology","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=4190&type=small&showNoImage","displayName":"Oleg Jardetzky","firstName":"Oleg","href":"http://mcp.stanford.edu/profiles/Oleg_Jardetzky","researchInterest":"Structure, dynamics and function of proteins involved in transport and regulatory processes; high resolution nuclear magnetic resonance studies of conformational transitions and protein folding; study of the mechanism of action of the trp-repressor, ankyrin-domain proteins and the development of programs to calculate protein solution structure"},{"lastName":"Jackson","clinicalFocus":[{"focus":"Neurological Surgery"}],"appointments":[],"imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=7251&type=small&showNoImage","displayName":"Paul Jackson, MD, Ph.D.","firstName":"Paul","href":"http://mcp.stanford.edu/profiles/Paul_Jackson","researchInterest":""},{"lastName":"Hilger","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Molecular & Cellular Physiology"}],"primaryAppointment":"Postdoctoral Research fellow, Molecular & Cellular Physiology","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=33669&type=small&showNoImage","displayName":"Daniel Hilger","firstName":"Daniel","href":"http://mcp.stanford.edu/profiles/Daniel_Hilger","researchInterest":""},{"lastName":"Bertaccini","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor - Med Center Line,Anesthesia"},{"appointment":"Professor - Med Center Line,Anesthesia"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Associate Professor - Med Center Line,Anesthesia","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=4079&type=small&showNoImage","displayName":"Edward Bertaccini","firstName":"Edward","href":"http://mcp.stanford.edu/profiles/Edward_Bertaccini","researchInterest":"molecular modeling of anesthetic-protein interactions, molecular modeling of the ligand-gated ion channels"},{"lastName":"Gardner","clinicalFocus":[],"appointments":[{"appointment":"Professor,Medicine - Clinical Pharmacology"}],"primaryAppointment":"Professor,Medicine - Clinical Pharmacology","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=4500&type=small&showNoImage","displayName":"Phyllis Gardner","firstName":"Phyllis","href":"http://mcp.stanford.edu/profiles/Phyllis_Gardner","researchInterest":"Ion channels and signal transduction;  patch clamp and fluorometric analysis; cell and molecular biology; cystic fibrosis gene therapy."},{"lastName":"Trudell","clinicalFocus":[],"appointments":[{"appointment":"Professor,Anesthesia"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Anesthesia","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=4617&type=small&showNoImage","displayName":"James Trudell","firstName":"James","href":"http://mcp.stanford.edu/profiles/James_Trudell","researchInterest":"Molecular theories of anesthesia. My emphasis is on the molecular interactions of inhalational anesthetics and alcohol. I perform computational chemistry simulations on how these molecules bind to putative receptor sites. I am also interested in modeling receptor proteins in which chimeras cause loss or enhancement of anesthetic sensitivity."},{"lastName":"Sathiyamoorthy","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Structural Biology"}],"primaryAppointment":"Postdoctoral Research fellow, Structural Biology","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=21151&type=small&showNoImage","displayName":"Karthik Sathiyamoorthy","firstName":"Karthik","href":"http://mcp.stanford.edu/profiles/Karthik_Sathiyamoorthy","researchInterest":""},{"lastName":"Ferrell","clinicalFocus":[],"appointments":[{"appointment":"Professor,Chemical and Systems Biology"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Professor,Biochemistry"}],"primaryAppointment":"Professor,Chemical and Systems Biology","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=4656&type=small&showNoImage","displayName":"James Ferrell","firstName":"James","href":"http://mcp.stanford.edu/profiles/James_Ferrell","researchInterest":"My lab has two main goals: to understand mitotic regulation and to understand the systems-level logic of simple signaling circuits.  We often make use of Xenopus laevis oocytes, eggs, and cell-free extracts for both sorts of study.  We also carry out single-cell fluorescence imaging studies on mammalian cell lines.  Our experimental work is complemented by computational and theoretical studies aimed at identifying the design principles of regulatory circuits."},{"lastName":"Kornberg","clinicalFocus":[],"appointments":[{"appointment":"Professor,Structural Biology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Structural Biology","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=4308&type=small&showNoImage","displayName":"Roger Kornberg","firstName":"Roger","href":"http://mcp.stanford.edu/profiles/Roger_Kornberg","researchInterest":"We study the regulation of transcription, the first step in gene expression. The main lines of our work are 1) reconstitution of the process with more than 50 pure proteins and mechanistic analysis, 2) structure determination of the 50 protein complex at atomic resolution, and 3) studies of chromatin remodelling, required for transcription of the DNA template in living cells"},{"lastName":"Doniach","clinicalFocus":[],"appointments":[{"appointment":"Member,Bio-X"}],"primaryAppointment":"Member,Bio-X","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=8062&type=small&showNoImage","displayName":"Sebastian Doniach","firstName":"Sebastian","href":"http://mcp.stanford.edu/profiles/Sebastian_Doniach","researchInterest":""},{"lastName":"Nag","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Biochemistry"}],"primaryAppointment":"Postdoctoral Research fellow, Biochemistry","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=23884&type=small&showNoImage","displayName":"Suman Nag","firstName":"Suman","href":"http://mcp.stanford.edu/profiles/Suman_Nag","researchInterest":"Mutations in the beta-cardiac myosin (a molecular motor) cause disastrous effects by manifestation of hypertrophic and dilated cardiomyopathy, a leading cause of cardiac death. We hypothesize that the such mutations cause fundamental mechanistic changes in the motor which in turn affect the efficiency of the motor in several ways. My current research involves single molecule enzyme kinetics and force measurements to link intrinsic changes in motor function to the various clinical outcomes."},{"lastName":"Shukla","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Bioengineering"}],"primaryAppointment":"Postdoctoral Research fellow, Bioengineering","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=23493&type=small&showNoImage","displayName":"Diwakar Shukla","firstName":"Diwakar","href":"http://mcp.stanford.edu/profiles/Diwakar_Shukla","researchInterest":""},{"lastName":"Herschlag","clinicalFocus":[],"appointments":[{"appointment":"Professor,Biochemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Stanford Cancer Institute"},{"appointment":"Professor (By courtesy),Natural Sciences Cluster - Chemistry"},{"appointment":"Professor (By courtesy),Chemical Engineering"}],"primaryAppointment":"Professor,Biochemistry","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=4262&type=small&showNoImage","displayName":"Daniel Herschlag","firstName":"Daniel","href":"http://mcp.stanford.edu/profiles/Daniel_Herschlag","researchInterest":"Our research is aimed at understanding the chemical and physical behavior underlying biological macromolecules and systems, as these behaviors define the capabilities and limitations of biology. Toward this end we study folding and catalysis by RNA, as well as catalysis by protein enzymes."},{"lastName":"Gofman","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Structural Biology"}],"primaryAppointment":"Postdoctoral Research fellow, Structural Biology","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=34497&type=small&showNoImage","displayName":"Yana Gofman","firstName":"Yana","href":"http://mcp.stanford.edu/profiles/Yana_Gofman","researchInterest":""},{"lastName":"Liu","clinicalFocus":[],"appointments":[{"appointment":"Engr Res Assoc,Genetics"}],"primaryAppointment":"Engr Res Assoc,Genetics","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=9027&type=small&showNoImage","displayName":"Tianyun Liu","firstName":"Tianyun","href":"http://mcp.stanford.edu/profiles/Tianyun_Liu","researchInterest":""},{"lastName":"Frank","clinicalFocus":[],"appointments":[{"appointment":"Member,Bio-X"}],"primaryAppointment":"Member,Bio-X","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=8065&type=small&showNoImage","displayName":"Curtis Frank","firstName":"Curtis","href":"http://mcp.stanford.edu/profiles/Curtis_Frank","researchInterest":""},{"lastName":"Myers","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Stem Cell"}],"primaryAppointment":"Postdoctoral Research fellow, Stem Cell","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=13571&type=small&showNoImage","displayName":"Benjamin Myers","firstName":"Benjamin","href":"http://mcp.stanford.edu/profiles/Benjamin_Myers","researchInterest":""},{"lastName":"Wu","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Psychiatry & Behavioral Science"}],"primaryAppointment":"Postdoctoral Research fellow, Psychiatry & Behavioral Science","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=21045&type=small&showNoImage","displayName":"Dick Wu","firstName":"Di","href":"http://mcp.stanford.edu/profiles/Di_Wu","researchInterest":""},{"lastName":"Baldwin","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Biochemistry"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Biochemistry","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=6816&type=small&showNoImage","displayName":"Robert Baldwin","firstName":"Robert","href":"http://mcp.stanford.edu/profiles/Robert_Baldwin","researchInterest":"I closed my laboratory when I retired in 1998.  I continue to do research, chiefly in collaboration with Franc Avbelj, on problems of protein folding energetics, especially peptide backbone solvation,  and to write reviews."},{"lastName":"Yanofsky","clinicalFocus":[],"appointments":[{"appointment":"Professor Emeritus,Biology (School of Humanities and Sciences)"}],"primaryAppointment":"Professor Emeritus,Biology (School of Humanities and Sciences)","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=6252&type=small&showNoImage","displayName":"Charles Yanofsky","firstName":"Charles","href":"http://mcp.stanford.edu/profiles/Charles_Yanofsky","researchInterest":""}]}