{"result":[{"lastName":"Peltz","clinicalFocus":[],"appointments":[{"appointment":"Professor,Anesthesia"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Anesthesia","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=8527&type=small&showNoImage","displayName":"Gary Peltz","firstName":"Gary","href":"http://mcp.stanford.edu/profiles/Gary_Peltz","researchInterest":"The laboratory develops and uses state of the art genomic methods to identify genetic factors affecting disease susceptibility, and to translate these findings into new treatments. We have developed a more efficient method for performing mouse genetic analysis, which has been used to analyze the genetic basis for 16 different biomedical traits. We are developing novel methods, and have developed a novel experimental platform that replaces mouse liver with functioning human liver tissue."},{"lastName":"Strober","clinicalFocus":[{"focus":"Immunology and Rheumatology"},{"focus":"Rheumatology"}],"appointments":[{"appointment":"Professor,Medicine - Immunology & Rheumatology"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor,Medicine - Immunology & Rheumatology","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=4152&type=small&showNoImage","displayName":"Samuel Strober","firstName":"Samuel","href":"http://mcp.stanford.edu/profiles/Samuel_Strober","researchInterest":"Mechanisms of immune tolerance; regulatory processes in autoimmunity and transplantation and extrathymic T cell maturation."},{"lastName":"Michie","clinicalFocus":[{"focus":"Anatomic Pathology"},{"focus":"Pathology and Laboratory Medicine"}],"appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Pathology","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=4707&type=small&showNoImage","displayName":"Sara Michie","firstName":"Sara","href":"http://mcp.stanford.edu/profiles/Sara_Michie","researchInterest":"Lymphocyte/endothelial cell adhesion mechanisms involved in lymphocyte migration to sites of inflammation; regulation of expression of endothelial cell adhesion molecules."},{"lastName":"Utz","clinicalFocus":[{"focus":"Immunology and Rheumatology"},{"focus":"Rheumatology"}],"appointments":[{"appointment":"Professor,Medicine - Immunology & Rheumatology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Medicine - Immunology & Rheumatology","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=4001&type=small&showNoImage","displayName":"Paul Utz","firstName":"Paul","href":"http://mcp.stanford.edu/profiles/Paul_Utz","researchInterest":"The long-term research goal of Dr. Utz\u0092s laboratory is (1) to develop a better understanding of the pathogenic mechanisms underlying systemic lupus erythematosus (SLE) and other autoimmune diseases by exploring signaling pathways that are activated during apoptosis; and (2) to better understand the complicated process of programmed cell death."},{"lastName":"Robinson","clinicalFocus":[{"focus":"Immunology and Rheumatology"},{"focus":"Rheumatology"}],"appointments":[{"appointment":"Associate Professor,Medicine - Immunology & Rheumatology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Associate Professor,Medicine - Immunology & Rheumatology","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=4730&type=small&showNoImage","displayName":"William Robinson","firstName":"William","href":"http://mcp.stanford.edu/profiles/William_Robinson","researchInterest":"Our lab studies the molecular mechanisms of and develops therapies to treat autoimmune and rheumatic diseases, with a focus on rheumatoid arthritis, multiple sclerosis, and osteoarthritis. \r\n\r\nThe overriding objectives of our laboratory are:\r\n\r\n1. To investigate the mechanisms underlying autoimmune diseases.\r\n\r\n2. To develop diagnostics and therapeutics for autoimmune diseases.\r\n\r\n3. To investigate the role of inflammation in osteoarthritis."},{"lastName":"Chan","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Medical fellow, Medicine"}],"primaryAppointment":"Postdoctoral Medical fellow, Medicine","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=23335&type=small&showNoImage","displayName":"Steven Chan","firstName":"Steven","href":"http://mcp.stanford.edu/profiles/Steven_Chan","researchInterest":""},{"lastName":"Sobel","clinicalFocus":[],"appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Professor (By courtesy),Neurology & Neurological Sciences"}],"primaryAppointment":"Professor,Pathology","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=4269&type=small&showNoImage","displayName":"Raymond A. Sobel, M.D.","firstName":"Raymond","href":"http://mcp.stanford.edu/profiles/Raymond_Sobel","researchInterest":"We study cellular and molecular mechanisms of immune-mediated injury in central nervous system (CNS) tissues  that are altered in multiple sclerosis (MS). Tissues of patients and of animals with experimental allergic encephalomyelitis are analyzed using histology and immunohistochemistry.  We currently are studying the cross-recognition of neurons by antibodies against myelin proteolipid protein epitopes.  Similar cross-recognition may link anti-myelin immunity with neurodegeneration in MS."},{"lastName":"Maecker","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor (Research),Microbiology & Immunology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Associate Professor (Research),Microbiology & Immunology","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=25058&type=small&showNoImage","displayName":"Holden Maecker","firstName":"Holden","href":"http://mcp.stanford.edu/profiles/Holden_Maecker","researchInterest":"I'm interested in immune monitoring of T cell responses to chronic pathogens such as CMV, and the correlation of T cell response signatures with disease protection."},{"lastName":"Grumet","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Pathology"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Pathology","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=4535&type=small&showNoImage","displayName":"Frank Carl Grumet","firstName":"Frank","href":"http://mcp.stanford.edu/profiles/Frank_Grumet","researchInterest":"Work in our laboratory is focused on the study of the human major histocompatibility (HLA) complex. We are seeking to characterize the genes and gene products of this complex and to understand their role in determining transplantation and transfusion compatibility. Laboratory work on this topic ranges from clinical studies correlating graft rejection with HLA antigens identified by classical serology or DNA typing."},{"lastName":"Tato","clinicalFocus":[],"appointments":[{"appointment":"Research and Science Analyst,Institute for Immunity, Transplantaion and Infection"},{"appointment":"Acad Research & Pgrm Officer,Institute for Immunity, Transplantaion and Infection"}],"primaryAppointment":"Research and Science Analyst,Institute for Immunity, Transplantaion and Infection","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=25587&type=small&showNoImage","displayName":"Cristina M. Tato","firstName":"Cristina","href":"http://mcp.stanford.edu/profiles/Cristina_Tato","researchInterest":""},{"lastName":"Smith","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Neurology & Neurological Sciences"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Neurology & Neurological Sciences","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=7015&type=small&showNoImage","displayName":"Marion Smith","firstName":"Marion","href":"http://mcp.stanford.edu/profiles/Marion_Smith","researchInterest":""},{"lastName":"Weyand","clinicalFocus":[{"focus":"Immunology"},{"focus":"Vasculitis"},{"focus":"Rheumatoid Arthritis"}],"appointments":[{"appointment":"Professor,Medicine - Immunology & Rheumatology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Medicine - Immunology & Rheumatology","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=15618&type=small&showNoImage","displayName":"Cornelia Weyand","firstName":"Cornelia","href":"http://mcp.stanford.edu/profiles/Cornelia_Weyand","researchInterest":""},{"lastName":"Goronzy","clinicalFocus":[{"focus":"Vasculitis"},{"focus":"Rheumatoid Arthritis"},{"focus":"Immunology"}],"appointments":[{"appointment":"Professor,Medicine - Immunology & Rheumatology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Professor,Medicine - Immunology & Rheumatology","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=15394&type=small&showNoImage","displayName":"Jorg Goronzy","firstName":"Jorg","href":"http://mcp.stanford.edu/profiles/Jorg_Goronzy","researchInterest":""},{"lastName":"Barres","clinicalFocus":[],"appointments":[{"appointment":"Professor,Neurobiology"},{"appointment":"Member,Bio-X"},{"appointment":"Professor,Developmental Biology"},{"appointment":"Professor,Neurology & Neurological Sciences"}],"primaryAppointment":"Professor,Neurobiology","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=4239&type=small&showNoImage","displayName":"Ben Barres","firstName":"Ben","href":"http://mcp.stanford.edu/profiles/Ben_Barres","researchInterest":"Our lab is interested in the neuronal-glial interactions that underlie the development and function of the mammlian central nervous system."},{"lastName":"Fathman","clinicalFocus":[{"focus":"Immunology"},{"focus":"Immunology and Rheumatology"}],"appointments":[{"appointment":"Professor,Medicine - Immunology & Rheumatology"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Professor,Medicine - Immunology & Rheumatology","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=4479&type=small&showNoImage","displayName":"C. Garrison Fathman","firstName":"C","href":"http://mcp.stanford.edu/profiles/C_Fathman","researchInterest":"My lab of molecular and cellular immunology is interested in research in the general field of T cell activation and autoimmunity.   We use lentiviral mediated transduction of murine dendritic cells with immunoregulatory proteins for site specific and targeted immunotherapy. We have identified and characterized a gene (GRAIL) that seems to control T cell anergy.    We have recently characterized a gene (Deaf1) that seems to play a major role in peripheral tolerance in T1D."},{"lastName":"Parnes","clinicalFocus":[],"appointments":[{"appointment":"Emeritus Faculty, Acad Council,Medicine - Immunology & Rheumatology"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Emeritus Faculty, Acad Council,Medicine - Immunology & Rheumatology","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=4487&type=small&showNoImage","displayName":"Jane Parnes","firstName":"Jane","href":"http://mcp.stanford.edu/profiles/Jane_Parnes","researchInterest":"The lab is studying the mechanisms controlling B cell responsiveness and the balance between tolerance and autoimmunity.  B cells deficient in CD72 are hyperresponsive to stimulation through the B cell receptor.  We are examining the alterations in B cell signaling in these B cells and the mechanisms by which CD72 deficiency partially abrogates anergic tolerance.  We hope to learn how deficiency in CD72 leads to spontaneous autoimmunity and increased susceptibility to induced autoimmune disease."},{"lastName":"Hu","clinicalFocus":[],"appointments":[{"appointment":"Associate Professor,Obstetrics & Gynecology"},{"appointment":"Member,Stanford Cancer Institute"}],"primaryAppointment":"Associate Professor,Obstetrics & Gynecology","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=10405&type=small&showNoImage","displayName":"Mickey Hu","firstName":"Mickey","href":"http://mcp.stanford.edu/profiles/Mickey_Hu","researchInterest":""},{"lastName":"Mellins","clinicalFocus":[],"appointments":[{"appointment":"Professor - Med Center Line,Pediatrics - Human Gene Therapy"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Child Health Research Institute"}],"primaryAppointment":"Professor - Med Center Line,Pediatrics - Human Gene Therapy","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=5952&type=small&showNoImage","displayName":"Elizabeth Mellins","firstName":"Elizabeth","href":"http://mcp.stanford.edu/profiles/Elizabeth_Mellins","researchInterest":"Molecular mechanisms and intracellular pathways of antigen processing and presentation; structure/function of HLA-DR,-DM, -DO; HLA allele association with disease; disease mechanisms in systemic idiopathic juveile arthritis"},{"lastName":"Higgins","clinicalFocus":[{"focus":"Pathology and Laboratory Medicine"},{"focus":"Anatomic/Clinical Pathology"}],"appointments":[{"appointment":"Associate Professor - Med Center Line,Pathology"},{"appointment":"Member,Bio-X"}],"primaryAppointment":"Associate Professor - Med Center Line,Pathology","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=4038&type=small&showNoImage","displayName":"John Higgins","firstName":"John","href":"http://mcp.stanford.edu/profiles/John_Higgins","researchInterest":"I work as a diagnostic surgical pathologist doing translational research in renal neoplasia and medical renal disease and neoplastic and medical liver disease. Subspecialty areas of clinical interest include diagnostic immunohistochemistry, renal, hepatic and transplant pathology."},{"lastName":"Kurnellas","clinicalFocus":[],"appointments":[{"appointment":"Postdoctoral Research fellow, Neurology & Neurological Sciences"}],"primaryAppointment":"Postdoctoral Research fellow, Neurology & Neurological Sciences","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=14640&type=small&showNoImage","displayName":"Michael Kurnellas","firstName":"Michael","href":"http://mcp.stanford.edu/profiles/Michael_Kurnellas","researchInterest":""},{"lastName":"Brahic","clinicalFocus":[],"appointments":[{"appointment":"Consulting Professor,Genetics"}],"primaryAppointment":"Consulting Professor,Genetics","imageUrl":"http://mcp.stanford.edu/profiles/viewImage?facultyId=6667&type=small&showNoImage","displayName":"Michel Brahic","firstName":"Michel","href":"http://mcp.stanford.edu/profiles/Michel_Brahic","researchInterest":"The lesions of Parkinson's disease (PD) spread within the central nervous system (CNS) with characteristics of prion diseases. The prion in this case is a misfolded form of alpha-synuclein. We are investigating the mechanism of spread on alpha-synuclein prions with a special attention to axonal transport and transfer of prions between neurons. Understanding these pathways could lead to using drugs to slow down or halt disease progression."}]}